What are the Challenges in Using TNF for Cancer Therapy?
The use of TNF in cancer therapy faces significant challenges. Systemic administration of TNF can lead to severe side effects such as cytokine release syndrome. Moreover, the dual role of TNF in cancer complicates its therapeutic targeting. Strategies to overcome these challenges include targeted delivery systems, like nanoparticles, that can localize TNF activity to the tumor site, minimizing systemic toxicity.
