Are There Any Challenges in Using Hydroxamates for Cancer Treatment?
Despite their promising potential, the use of hydroxamates in cancer therapy faces several challenges. One major issue is the development of drug resistance, which can limit their long-term efficacy. Additionally, the non-specific inhibition of HDACs can lead to off-target effects and toxicity. Researchers are actively working on developing more selective HDAC inhibitors and combination strategies to overcome these limitations.
