Are There Any Resistance Mechanisms to BET Inhibitors?
Resistance to BET inhibitors can occur, and several mechanisms have been proposed. One potential mechanism is the upregulation of alternative pathways that compensate for the inhibited BET proteins. Another mechanism could involve mutations in the BET proteins themselves or in other components of the transcriptional machinery, reducing the efficacy of BET inhibitors. Research is ongoing to understand these resistance mechanisms better and develop combination therapies that can overcome them.
