Are There Any Smac Mimetics Currently in Clinical Trials?
Yes, several Smac mimetics are undergoing clinical trials. Notable examples include LCL161, Debio 1143 (previously known as AT-406), and Birinapant. These compounds are being evaluated both as monotherapies and in combination with other treatments like chemotherapy, immunotherapy, and targeted therapies. Early results have shown promise, but further studies are needed to confirm their clinical benefits and optimal use.
