Are There Any Therapeutic Approaches to Enhance MHC Class I Expression?
Yes, several therapeutic strategies aim to enhance MHC Class I expression on cancer cells. These include the use of cytokines like interferons, which can upregulate MHC Class I molecules, and gene therapy approaches designed to restore or increase MHC Class I expression. Additionally, some small molecule drugs are being investigated for their ability to modulate MHC Class I surface expression, thereby improving the efficacy of T cell-mediated cancer therapies.
