What Role Do MHC Class I Molecules Play in Tumor Microenvironment?
The tumor microenvironment can significantly influence the expression and function of MHC Class I molecules. Factors such as hypoxia, cytokines, and other tumor-derived signals can alter MHC Class I expression and function. Understanding these interactions is critical for developing therapies that can effectively modulate the immune response within the tumor microenvironment, thereby enhancing the overall effectiveness of cancer immunotherapy.
