While Ki-67 staining provides valuable information, it is not without limitations. One major issue is the variability in assessment, as different laboratories may use different antibodies, staining protocols, and scoring methods. This can lead to inconsistencies in the reported Ki-67 index. Efforts are ongoing to standardize these procedures to improve reliability. Additionally, Ki-67 is just one biomarker among many, and its results should be interpreted in the context of other clinical and pathological findings.
