Several formins have been linked to cancer, including Diaphanous-related formins (DIAPH1, DIAPH2, and DIAPH3), formin-like proteins (FMNL1, FMNL2, and FMNL3), and Delphilin (PHLDB1). Among these, DIAPH3 has received particular attention for its role in promoting cellular invasion and metastasis in breast cancer and other malignancies.
