Are There Specific Cancers Associated with DNA Repair Defects?
Yes, specific cancers are often linked to defects in particular DNA repair pathways. For instance:
Lynch syndrome is associated with defective mismatch repair genes, leading to colorectal and other cancers. Defects in the NER pathway are linked to Xeroderma Pigmentosum, a condition that predisposes individuals to skin cancer. BRCA1 and BRCA2 mutations are strongly associated with breast and ovarian cancers.