Are There Specific Genotype-Phenotype Correlations in Certain Cancers?
Yes, specific cancers often have characteristic genetic mutations that correlate with particular phenotypes. For example, in Chronic Myeloid Leukemia (CML), the presence of the BCR-ABL fusion gene (resulting from the Philadelphia chromosome translocation) is a hallmark. This genetic alteration leads to the production of an abnormal tyrosine kinase that promotes cancer cell growth, and its presence is associated with specific clinical features and treatment responses.
