Several therapeutic interventions are being explored to reduce AGE levels and mitigate their effects:
AGE Inhibitors: Compounds like aminoguanidine and pyridoxamine can inhibit AGE formation and have shown promise in preclinical studies. AGE Breakers: Agents like alagebrium chloride can break preformed AGEs and have been investigated for their potential benefits in reducing AGE accumulation. Antioxidants: Dietary antioxidants and pharmacological agents can help reduce oxidative stress and inhibit AGE formation. RAGE Blockers: Targeting the RAGE signaling pathway with specific inhibitors can help prevent AGE-induced cellular damage and inflammation.
