AGEs can be measured using various methods, including skin autofluorescence, blood plasma levels, and tissue biopsy. Skin autofluorescence is a non-invasive technique that measures the natural fluorescence emitted by AGEs in the skin. Blood plasma levels of specific AGEs can be quantified using techniques like ELISA (enzyme-linked immunosorbent assay) or mass spectrometry. Tissue biopsies, though more invasive, provide direct evidence of AGE accumulation in specific organs or tissues.