Given the pivotal role of MMPs in cancer, several therapeutic strategies have been explored, including: - MMP Inhibitors (MMPIs): Small molecules or antibodies that specifically inhibit MMP activity. Despite initial promise, many MMPIs have faced challenges in clinical trials due to lack of specificity and adverse side effects. - Gene Therapy: Approaches to silence or downregulate MMP expression using siRNA or antisense oligonucleotides. - Natural Compounds: Certain natural compounds like doxycycline have shown inhibitory effects on MMP activity and are being investigated for therapeutic use.
