What are the Major Types of MMPs Involved in Cancer?
Several MMPs have been implicated in cancer, including: - MMP-2 (Gelatinase A) and MMP-9 (Gelatinase B): Associated with the degradation of type IV collagen, a major component of basement membranes. - MMP-1 (Collagenase-1): Involved in the breakdown of interstitial collagens. - MMP-7 (Matrilysin): Known for its broad substrate specificity and role in cancer cell invasion. - MMP-14 (MT1-MMP): A membrane-type MMP crucial for pericellular proteolysis and cell migration.
