Targeting TME acidification is a promising therapeutic strategy. Potential approaches include:
Buffer Therapy: Using buffering agents to neutralize the acidic pH of the TME. Inhibitors of Glycolysis: Drugs that inhibit glycolytic enzymes can reduce acid production. CAIX Inhibitors: Blocking CAIX can prevent the regulation of pH, disrupting tumor cell survival. Proton Pump Inhibitors: Targeting proton pumps can limit the export of protons, reducing extracellular acidification.
