Can Actin Filament Modulators be Used as Cancer Therapies?
Given their role in cancer progression, actin filament modulators are being investigated as potential cancer therapies. Drugs that interfere with actin polymerization or depolymerization can inhibit cancer cell migration and invasion. For instance, compounds like cytochalasins and latrunculins, which disrupt actin filament dynamics, have shown promise in preclinical studies. However, due to the critical functions of actin in normal cells, the challenge lies in achieving therapeutic specificity to minimize toxicity.
