What is the Impact of Actin-associated Proteins in Cancer?
Actin-associated proteins, such as cofilin, profilin, and Arp2/3 complex, regulate the organization and dynamics of actin filaments. These proteins are often dysregulated in cancer, impacting cell motility and invasiveness. For example, cofilin overexpression has been linked to increased metastatic potential in various cancers. Targeting actin-associated proteins offers another strategy for disrupting the actin cytoskeleton in cancer cells, potentially hindering their ability to metastasize.
