Can Antigen Processing Deficiencies Be Targeted Therapeutically?
Yes, there are several approaches to target antigen processing deficiencies therapeutically:
1. Immunomodulatory Drugs: Agents that upregulate the expression of proteasome components, TAP, or MHC molecules can enhance antigen presentation. 2. Gene Therapy: Correcting genetic defects in the antigen processing pathway through gene therapy holds potential for restoring immune recognition of cancer cells. 3. Checkpoint Inhibitors: By blocking immune checkpoints, these inhibitors can enhance T-cell activation and improve the immune system's ability to recognize and attack tumor cells despite antigen processing deficiencies.
