Why Are Antigen Processing Deficiencies Significant in Cancer?
Cancer cells often exploit antigen processing deficiencies to avoid immune detection. By downregulating or mutating components of the antigen processing machinery, they can reduce the presentation of tumor antigens on their surface. This allows them to escape recognition and destruction by cytotoxic T-cells, contributing to tumor growth and metastasis. Understanding these deficiencies is crucial for developing strategies to enhance immune detection and improve cancer therapies.
