Can Dysregulated Replication be Targeted for Cancer Therapy?
Absolutely. Several therapeutic strategies are designed to target dysregulated replication:
Checkpoint Inhibitors: Drugs that restore function to cell cycle checkpoints. DNA Repair Inhibitors: Target proteins involved in DNA damage repair, such as PARP inhibitors. Targeted Therapies: Drugs that specifically target mutated oncogenes, like EGFR inhibitors and BRAF inhibitors. Cell Cycle Inhibitors: Compounds that inhibit cyclin-dependent kinases (CDKs) to halt uncontrolled cell division.
