What Are the Consequences of Dysregulated Replication?
The consequences of dysregulated replication are severe and multifaceted:
Genomic Instability: Leads to an increased mutation rate and chromosomal aberrations. Oncogene Activation: Overexpression or mutation of oncogenes can drive uncontrolled cell proliferation. Loss of Tumor Suppressor Function: Inactivation of tumor suppressor genes removes critical brakes on cell division. Aneuploidy: Abnormal number of chromosomes, contributing to cancer heterogeneity and drug resistance.
