Can MHC Class I Expression Be Modulated for Cancer Therapy?
Yes, modulating MHC Class I expression is a potential strategy in cancer immunotherapy. Various approaches aim to enhance MHC Class I expression on tumor cells to improve their recognition by the immune system. These include the use of interferons, which are cytokines that can upregulate MHC Class I expression, and checkpoint inhibitors, which can reinvigorate CTL activity against tumors.
