What Role Do Tumor Cells Play in MHC Class I Expression?
Cancer cells often develop mechanisms to evade immune detection. One common strategy is the downregulation or loss of MHC Class I expression. By reducing the levels of MHC Class I molecules on their surface, cancer cells can avoid recognition by CTLs, thus escaping immune destruction. This evasion tactic is associated with a poorer prognosis and increased tumor aggressiveness.
