Can the Microenvironment Influence Immunity in Cancer?
Yes, the _tumor microenvironment_ (TME) significantly influences the efficacy of the immune response. The TME includes various cell types, extracellular matrix components, and signaling molecules that can either support or inhibit immune activity. For instance, _myeloid-derived suppressor cells (MDSCs)_ and _cancer-associated fibroblasts (CAFs)_ within the TME can promote immunosuppression and tumor progression.
