Cancer cells often rely on the dysregulation of gene expression for their growth and survival. BET proteins, especially BRD4, play a significant role in the transcription of oncogenes like MYC. By inhibiting BET proteins, BETi reduce the transcription of these oncogenes, leading to cell cycle arrest, apoptosis, and reduced tumor growth. Additionally, BETi can disrupt the formation of super-enhancers, which are large clusters of regulatory elements that drive the high-level expression of genes critical for cancer cell survival.
