Diagnosis of gastrinomas involves a combination of clinical evaluation, biochemical tests, and imaging studies. Key diagnostic steps include:
Measuring fasting serum gastrin levels: Elevated levels may indicate a gastrinoma. Secretin stimulation test: Helps confirm the diagnosis by assessing the response of gastrin levels to secretin. Imaging studies: Techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and somatostatin receptor scintigraphy (SRS) are used to locate the tumor and assess metastasis. Endoscopic ultrasound (EUS): This is often used to visualize and biopsy tumors in the pancreas and duodenum.
