The identification of novel genes in cancer involves a combination of advanced technologies and methodologies:
Next-Generation Sequencing (NGS): This technology allows for high-throughput sequencing of cancer genomes, helping to identify mutations and alterations in previously unknown genes. Bioinformatics: Computational tools and algorithms analyze large datasets to pinpoint potential novel genes associated with cancer. Functional Genomics: Techniques like RNA interference (RNAi) and CRISPR-Cas9 are used to study gene function and validate the role of novel genes in cancer. Comparative Genomics: Comparing cancer genomes with normal genomes can highlight novel genes that are specifically altered in cancer.
