How Can Excision Repair Mechanisms Be Targeted in Cancer Therapy?
Understanding excision repair pathways allows for the development of targeted cancer therapies. Inhibitors of specific repair proteins can sensitize cancer cells to chemotherapy and radiation by exacerbating DNA damage. For instance, PARP inhibitors target BER and are particularly effective against cancers with existing DNA repair deficiencies, such as BRCA-mutated breast and ovarian cancers.
