Several strategies have been explored to inhibit MDR proteins and enhance the efficacy of chemotherapy:
Inhibitors: Compounds like verapamil, cyclosporine A, and tariquidar have been studied for their ability to inhibit MDR proteins, although their clinical use has been limited by toxicity and lack of specificity. RNA Interference: Techniques such as siRNA and shRNA can be used to downregulate the expression of MDR genes, thereby reducing the levels of MDR proteins in cancer cells. Nanoparticle Delivery: Encapsulating chemotherapeutic drugs in nanoparticles can help bypass MDR proteins and deliver drugs directly to cancer cells.
