What Enzymes are Involved in Cholesterol Biosynthesis in Cancer Cells?
The cholesterol biosynthesis pathway includes several key enzymes, such as HMG-CoA reductase, squalene synthase, and farnesyl diphosphate synthase. Among these, HMG-CoA reductase is often considered the rate-limiting enzyme. Cancer cells frequently show overexpression of these enzymes, leading to enhanced cholesterol production. Targeting these enzymes could offer therapeutic potential in cancer treatment.
