How Can Targeting the Pentose Phosphate Pathway be Therapeutic in Cancer?
Given the importance of the PPP in cancer cell metabolism, targeting this pathway presents a potential therapeutic strategy. Inhibitors of G6PD and other PPP enzymes can disrupt the redox balance and nucleotide synthesis in cancer cells, leading to increased oxidative stress and reduced proliferation. Combining PPP inhibitors with other treatments, such as chemotherapy or radiotherapy, could potentiate anti-cancer effects by further destabilizing cancer cell metabolism.
