What Enzymes are Involved in the Pentose Phosphate Pathway?
Key enzymes in the PPP include glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconolactonase, 6-phosphogluconate dehydrogenase, ribose-5-phosphate isomerase, and transketolase. Among these, G6PD is often upregulated in cancer cells, contributing to their enhanced PPP activity. Inhibition of G6PD and other PPP enzymes has been shown to reduce the growth and survival of various cancer types.
