Are There Any Clinical Trials Targeting the Pentose Phosphate Pathway?
While direct inhibitors of the PPP are still under investigation, several clinical trials are exploring compounds that indirectly affect PPP activity. For instance, inhibitors of PI3K and AKT signaling pathways, which regulate glucose metabolism, can also impact PPP activity. Additionally, some trials are testing antioxidants that may deplete NADPH levels, thereby indirectly targeting the PPP.
