How Can the β Catenin Pathway be Targeted for Cancer Therapy?
Given its significant role in cancer, the β catenin pathway is a promising therapeutic target. Strategies to inhibit this pathway include:
1. Small Molecule Inhibitors: Compounds that target various components of the pathway, such as tankyrase inhibitors that stabilize axin, have shown potential. 2. Monoclonal Antibodies: These can target Wnt ligands or Frizzled receptors to prevent pathway activation. 3. Gene Therapy: Techniques to correct mutations in APC or β catenin genes are under investigation. 4. Natural Compounds: Certain natural products, like curcumin, have been found to modulate β catenin signaling.
