What are the Challenges in Targeting the β Catenin Pathway?
Despite its potential, targeting the β catenin pathway poses several challenges:
1. Specificity: Achieving precise inhibition without affecting normal cellular functions is difficult. 2. Resistance: Cancer cells may develop resistance to β catenin inhibitors. 3. Toxicity: Systemic inhibition of the pathway can lead to toxic side effects due to its role in normal tissue homeostasis. 4. Heterogeneity: The pathway's role can vary significantly among different cancer types and even among patients with the same type of cancer.
