What Types of Cancers are Associated with β Catenin Pathway Dysregulation?
Several cancers exhibit aberrant activation of the β catenin pathway:
1. Colorectal Cancer: Mutations in the APC gene are commonly found, leading to the accumulation of β catenin and activation of oncogenic transcription. 2. Hepatocellular Carcinoma: Mutations in β catenin and other pathway components are frequently observed. 3. Breast Cancer: Alterations in the Wnt/β-catenin signaling pathway are linked to certain subtypes. 4. Gastrointestinal Cancers: Various gastrointestinal cancers show dysregulated β catenin signaling. 5. Melanoma: Aberrant activation of the pathway is implicated in melanoma progression.
