How do Cancer Therapies Target DNA Repair Mechanisms?
Certain cancer therapies exploit the deficiencies in DNA repair mechanisms. For example:
- PARP inhibitors: Target HR-deficient tumors, such as those with BRCA mutations, by blocking the repair of single-strand breaks, leading to cell death. - Platinum-based chemotherapy: Causes DNA crosslinks that are particularly lethal to cells with defective repair pathways.
