How Do Chromatin Remodeling Genes Contribute to Cancer Development?
Chromatin remodeling genes contribute to cancer development by disrupting the normal regulation of gene expression. For instance, loss-of-function mutations in these genes can lead to the inactivation of tumor suppressor pathways, while gain-of-function mutations can activate oncogenic pathways. Additionally, alterations in chromatin remodeling can affect DNA repair mechanisms, increasing genomic instability and the likelihood of further mutations.
