How are Chromatin Remodeling Genes Targeted in Cancer Therapy?
Given their crucial role in cancer, chromatin remodeling genes are promising targets for cancer therapy. Several strategies are being explored, including:
Small molecule inhibitors: Targeting specific components of chromatin remodeling complexes to inhibit their activity. For example, EZH2 inhibitors are being tested in clinical trials for various cancers. Epigenetic drugs: Drugs such as HDAC inhibitors that modify the epigenetic landscape, thereby restoring normal gene expression. Immunotherapy: Exploiting the immune system to recognize and attack cancer cells with specific chromatin remodeling gene mutations.
