CNVs can contribute to cancer by altering the dosage of oncogenes and tumor suppressor genes. Oncogenes, when amplified, can lead to unchecked cell growth and proliferation, a hallmark of cancer. Conversely, the deletion of tumor suppressor genes can remove critical regulatory mechanisms that control cell division, leading to tumorigenesis. The presence of CNVs can disrupt normal cellular functions and facilitate the progression of cancer by providing cells with a growth advantage.
