DNA demethylating agents, also known as DNA methyltransferase inhibitors (DNMTi), inhibit the activity of DNA methyltransferases, enzymes responsible for adding methyl groups to DNA. By inhibiting these enzymes, DNMTi can induce the reactivation of silenced genes, promoting apoptosis and reducing proliferation in cancer cells. Two commonly used DNMTi are 5-azacytidine and decitabine.
