How Do DNA-Protein Crosslinks Contribute to Cancer?
The formation of DPCs can hinder the proper function of DNA replication and repair mechanisms, leading to mutations and chromosomal aberrations. These alterations in the genome can activate oncogenes or deactivate tumor suppressor genes, propelling the initiation and progression of cancer. Furthermore, the accumulation of DPCs can lead to cell death or senescence, contributing to the development of a tumor microenvironment that supports cancer growth.
