What Role Do DNA-Protein Crosslinks Play in Cancer Therapy?
Interestingly, the formation of DPCs is also a mechanism used by certain chemotherapy agents to kill cancer cells. Drugs like cisplatin and mitomycin C induce DPCs, exploiting the fact that cancer cells often have defective DNA repair pathways. This leads to an accumulation of DNA damage, triggering cell death. The therapeutic effectiveness of these drugs highlights the dual role of DPCs in both cancer pathogenesis and treatment.
