Interleukins can have both pro-tumorigenic and anti-tumorigenic effects on cancer. Some interleukins, such as IL-2, enhance the immune response against tumors by activating natural killer (NK) cells and cytotoxic T lymphocytes. Conversely, other interleukins like IL-10 and IL-6 may promote tumor growth by inhibiting anti-tumor immune responses and promoting angiogenesis.