What are the Challenges in Using Interleukins for Cancer Treatment?
There are several challenges associated with the use of interleukins in cancer therapy:
- Toxicity: High doses of interleukins can cause severe side effects, including capillary leak syndrome, which can be life-threatening. - Short Half-life: Many interleukins have a short half-life, requiring frequent administration or the development of modified forms with longer activity. - Complex Immune Modulation: Interleukins can have dual roles, promoting or inhibiting tumor growth depending on the context. This complexity makes it challenging to predict their effects accurately.
