mlh1, msh2, msh6, and pms2

How do mutations in these genes contribute to cancer?

Mutations in any of these genes can disrupt the MMR system, leading to an accumulation of genetic mutations. This condition is known as microsatellite instability (MSI). High levels of MSI are commonly seen in certain types of cancer, such as colorectal cancer, endometrial cancer, and ovarian cancer. When MMR genes are defective, the risk of developing these cancers increases significantly.

Frequently asked queries:

Partnered Content Networks

Relevant Topics