What types of cancer are most commonly associated with these gene mutations?
Mutations in MLH1, MSH2, MSH6, and PMS2 are most commonly associated with Lynch syndrome, also known as hereditary non-polyposis colorectal cancer (HNPCC). Individuals with Lynch syndrome have a higher risk of developing colorectal cancer, endometrial cancer, stomach cancer, ovarian cancer, and several other types of cancer. Among these genes, mutations in MLH1 and MSH2 are the most frequent.
