How Do Nuclear Receptors Interact with Other Signaling Pathways?
Nuclear receptors often interact with other cell signaling pathways, influencing cancer development and progression. For example, ER can cross-talk with growth factor signaling pathways such as the PI3K/AKT pathway, enhancing the survival of breast cancer cells. These interactions can complicate treatment responses and contribute to therapy resistance. Hence, a deep understanding of these cross-talk mechanisms is crucial for developing more effective cancer therapies.
