Orphan nuclear receptors are receptors whose endogenous ligands are not well-defined. Despite the lack of known ligands, these receptors are implicated in various cancers. For example, the NR4A1 receptor, also known as Nur77, has been identified in several cancer types and is involved in regulating cell proliferation and apoptosis. Understanding the function of orphan receptors and their role in cancer biology could open new avenues for therapeutic intervention.
