How Do Oncogenes and Tumor Suppressors Influence Glycolysis?
Oncogenes and tumor suppressors play a significant role in metabolic reprogramming. For instance, the MYC oncogene promotes the expression of glycolytic enzymes, increasing glycolysis. Conversely, the tumor suppressor p53 can inhibit glycolysis through various mechanisms, including the regulation of TIGAR (TP53-induced glycolysis and apoptosis regulator), which lowers glycolytic flux.
